You’ve got the premier CMags + Patch speed-kill team already. That one’s killer on offense. You’ll want to max out Patch, though, for the extra damage and health.
For hybrid offense/defense, LThor + Hood/UDaken and Sentry + UDaken seem to be the top teams at the moment.
For defense alone, Hulk + UDaken is good.
Basically, Patch, LT, CMags, Hulk, and Hood would be the characters you’ll want to invest Iso in, in that order. As for covers, try to get those remaining 3 covers for Hood, and try to get more UDaken covers.
For better defense with max healing, go 5/5/3. For faster offense with reduced healing, go 5/3/5. 5/4/4 is a nice compromise, I suppose. I currently have 5/3/3, and I’ll just be going wherever my cover drops take me.
Based on your existing team, without any more leveling, CMags + Patch for offense and defense.
Given your roster and a lot of Iso, CMags + Patch for offense, LT + Hood/Hulk for defense.
Given your roster, a lot of Iso, and a lot of HP for direct cover buys: 5/5/3 CMags + 5/3/5 Patch for fast but extended pushes, Patch + Hulk for some shorter-term fun, and probably x/5/x Sentry + 5/5/3 UDaken for short/medium pushes & defense. Throw 5/5/3 Hood into the mix for good measure.