Please. PLEASE. Never EVER make 3* Thanos the uberbuffed required character if ANY of the 3* required Story nodes is a wave node.
I believe he will be the 3* essential for the Enemy of the State PvE
Good news: I’ve never seen a required character in a wave node unless it’s a special boss event.
All of the 3* required character nodes in Enemy of the State are wave nodes except in the Hell’s Kitchen sub.