For many characters, the AI plays rather dumbly. It should be possible to set strategies for a few characters.
GENERAL – How often to use a power. For example, She Hulk’s Reprieve could be set to Never use or Normal usage.
Invisible Woman – Force Bubbles. Choose a color to lock out.
BWGS – Deceptive Tactics. Fill a line.
Human Torch – Flame Jet. Only have 1 Flame Jet at a time.
IM40 – Recharge. Use at a lower Cover level.
The Hood – Twin Pistols. Choose a color to optimize.
For everyone: don’t use Thorned Rose if doing so would down the active character
Captain America: prioritize overwriting enemy special tiles when using shield powers
juggy dont headbut if below health line, ditto for ares sunder etc.
if a T match is possible, dont go for the 4 in a row
(but why do we want to make it harder to win? - perhaps should get the AI to only match environment tiles, but never use them)
I think that the starting point should be prioritize which character for the same color when in defense mode.
e.g. : a team with Thor and Ares :
(or any combinaison you want 
)