I managed this on my second try with my level 100 4/5/4 Kraven. I didn’t keep an eye on red as closely as I should have in the first attempt, and one tooth (and one nail) took my Kraven out of the picture for good. One the second try I focused mainly on denying red, as Kraven can start cranking up some damage once the enemy gets a few special tiles out. I also let Kraven borrow Taskmaster’s sword, to wipe the goody-two-shoes look off of Black Panther’s face.
I never use Kraven, so I had to keep checking what his powers do. In the end I wore Panther down with the passive damage.