Success!!!
L150, 4/4/5, +2 B/G, +100% all, +50% B/G
Got black out early, purple light board. very very luck. Took one diabolical plot mid way through dropping me to 800 HP, but my protect tiles kept me going as Doom matched my countdown and then a protect to boost my health back up.
Doom seems to have 4 black and blue covers this time around, unsure about Purple. Might be 4 covers there too… My first attempt failed miserably, but I’ll try again later.
Yup, called it.
They removed one cover on Doom, which doesn’t make enough of a difference to make this any easier.
My champed Stretch was down to 3K when I finally whittled Doom down.
Coming in to post pretty much this exact comment. My Mr F is LVL 271, and he had about 3K health left at the end of the match. I used +2 blue, +2 Black and +2 All AP to start. Doom’s first six matches were in his colors, which really didn’t help my case much. Doom managed to activate all three of his abilities at various points in the match, although I was able to mach away three of the red attack tiles very quickly.
Once I got Imaginaut out, the red, yellow and green tiles started to appear. I think I ended the match with over 25 red and yellow, with the timer on Imaginaut at 7 thanks to a couple of really nice cascades.
LT stockpiled for when I finish champing the four stars that have 13 covers…
My Stretch at lvl 180 succeded with 927 LP left…I have been lucky because this is one of (or better THE) most difficult battle in Clash of Titans. Doom managed to hit me once with his 
and deplete my life bar, but Mr.F survived 
Now I am exhausted 
Ended taking my 535 up to 200 for my 5th go with boosts coming out my ears, scraped through in the end thanks to a purple light board that gave me time to get some powers out.
Got a green for my already 5/2/5 X23 to further compound the distasteful experience.
At least I did it this time.
Thx for tuning this down guys
I took 3 tries but I got there in the end with my lvl 160 - 3/4/5 
(not having 4 
makes it tough as the 1 turn stun is just not enough)
First 2 tries I was obliterated but I got a very good board for the 3rd try and managed to keep pink/black away while whittling him down. Finished with nearly all of my health as on the last few turns he keep matching the protect tiles.
The reward for my effort 
= champion level
Lvl 272 Reed here. I went with +2 blue, +2 all, 100% damage.
It STILL took three tries, and even then it was luck on getting a lot of blue early to keep Doom stunned. Ended with around 9000 hit points remaining with Doom about to unload his purple and red.
Got a needed black Totes Hulk for it!
Tried it once and 
laughed in the face of my LVL 111 1/0/5
. Think I’ll leave it at that and hope for more luck next time
2 attempts
1st with my level 120 5/3/5 with no boosts. Lost.
2nd raised him to 140 and added all color boosts necessary.
Got a pretty lucky board where doom wasn’t making any purple matches. In fact, only power he got off was one summon demons. Pretty much was able to keep him stunned the entire time and threw several imaginenauts at him. Health never dipped below 5k, just was a boring fight since every thing was match damage pretty much.
Got a champ level Fisk continuing my streak of not pulling 5s from latest legends.
Mine is champed, lv 274, 5/3/5. I was lucky to beat him on the first try. Did a Black Attack and luckily it didn’t ever get matched away, sometimes occurring more than once per turn. Also did some blue stunnas, and everything came up roses.
Last time: 0-for-16 with 2/4/5 lv133 Mr. F.
This time, won on my 4th attempt with 5/3/5 lv133 Stretcho, +2g/bk, +2b/p, +100% damage. Fight is still annoying, and I feel fortunate that I won when I did.
Strat is simple: since Reed has no nukes, you have to beat Doom with match damage, preferably accelerated by his black. Hopefully you’ll get a few blues as well to to slow him down and exert a little board control.
At low levels with only 6-7k health, denying purple is a priority, because if Doom fires it once, it’ll eat most (if not all) of Reed’s health. Next priority is black, because that will boost your damage and keep Doom from laying out attack tiles.
Denying stuff wasn’t really a problem for me, because in typical Crash style, every board was overloaded with colors I couldn’t use. I managed to get off two blue stuns on my first attempt, but the fight takes so long that a few 3-turn stuns are a drop in the bucket, especially if there’s no black or blue to grab while Doom is stunned. I got two black CD tiles down, and both times Doom just magically cascaded them away. He eventually got off a purple and that was it.
My second and third tries, Doom cascaded into lots of purple and black matches, and I ended up just retreating both times to save health.
My fourth try, I put down a black CD early and was able to completely deny purple. So I was able to whittle him down at a decent pace, and even snuck in a blue stun to get in a few turns of free damage. He still got off a blue and a black, so I was down to 2k health when I finally beat him.
reward: 
now 0/1/1.
I just played a test game with my Level 139 1/3/3 to test the waters.
He got off a black and managed to kill me quickly with 13K to spare. Don’t think this one will make much difference boosted.
2/0/4 lvl 147. Took about a dozen or so tries, but finally got a purple light board with an early imaginaut. Even with only one demons, it went down to the wire.
for my efforts made me 
Tried once with my level 94 4/2/5 and failed miserably. I really don’t want to use ISO on him but I guess I should to get the LT
Took 3 tries lvl 201 4/3/5.
I tried to use all damage boost, but the game crashed and ate my boost wasted health pack Thanks developers.
Playing on steam do i get to use intercepts or something relative, nope.
The LT gave 
0/0/2
Haven’t posted in ages but wanted to reiterate how useless Reed is in Crash like everyone else has already mentioned.
2/5/5 Lvl 200 (awful luck with covers I don’t want/had some ISO to burn when I was drunk one night, lol) was useless on 9/10 tries. In this config, low chance of healing from protect tiles, one turn stun and still worse match damage with imaginut than Vision Heavy…a 12 cover 4* should be semi-functioning…
I thought the devs acknowledged how OP Dr. Doom is vs. Reed and was going to knock him down to at least level 220.
Back to the unused pile, Reed! Your one day of play is done!
Level 229 3-5-3. Haven’t even gotten that close in 7 tries. With boosts, without boosts – doesn’t matter. Reed simply does not have the firepower. If Doom gets one of his powers off – any one – the match is probably over.
I really don’t think that a character 2 covers away from max should struggle in a Crash this badly.
Beat it on my 5th try (i think) with my 3/5/3 lvl 140 Mr. F. Got very, very lucky. And then more lucky: Dr. Strange 5*!
Only cared about matching blue and black. He fired his purple at one point and almost killed me.. ended up winning with <100 health
Edit: Boosts used were +all stockpile, +blue/purple stockpile, +blue/purple damage