Ooh; I’d love some daily PvE! 
If it’s not too wild, how about 7 dailies on a rotation - standard model being…
5 Missions per map, must be completed in sequence.
1st - 4th Missions are repeatable and primarily against generic foes.
→ 100 ISO first time completion.
→ Rewards: 100 ISO, 250 ISO, Standard Cover, boost appropriate to that day’s map (usually a Target lock).
5th Mission being a boss fight that isn’t repeatable.
→ First time completion bonus is the big reward for the map e.g. 50 HP, 500 ISO, 3 Standard Covers.
→ Rewards: 250 ISO.
No character conversation screens, just flavour text on mission screens.
No required characters, scores, league tables etc.
E.g. Maggia Monday
Environment: City.
Boost Reward: Maggia Target Lock.
1st Mission: 3 Thugs - Trouble on the streets.
2nd Mission: 2 Thugs, 1 Muscle - Asking questions.
3rd Mission: 1 Muscle (high level) - Maggia enforcer.
4th Mission: 2 Thugs, 1 Don - Taking on the boss?
5th Mission: 2 Muscle, The Hood - True crime-lord unmasked.
Big Reward: 500 ISO - The Hood has been running a black market in ISO.
However; maybe make one day extra special - possibly Sunday or just pick the quietest day for other events (Thursday I guess).
5 Missions on the map map, must be completed in sequence.
1st - 4th Missions are repeatable and are against supervillain foes.
→ 100 ISO first time completion.
→ Rewards: 100 ISO, 500 ISO, Standard Cover, boost appropriate to the map.
5th Mission being a boss fight that isn’t repeatable.
→ First time completion bonus is an Heroic Cover.
→ Rewards: 500 ISO.
As for other dailies, no conversation screens, league tables etc.
E.g. Day of Reckoning
Environment: City.
Boost Reward: Dark Avengers Target Lock (very desirable for PvE).
1st Mission: Soldier, Soldier, Bullseye.
2nd Mission: Pyro, Yelena Belova, Daken.
3rd Mission: Lieutenant, Venom, Moonstone.
4th Mission: Ragnorak (175?).
5th Mission: Ares (240?).
I put Ares last as he has superior powers and 3 colours, plus Ragnorak already got to be the PvE finale in the prologue.
Think it’s better to have 1 lone super character to give newer players a chance, since Widow’s Sting and Symbiote Snare lower the playing field a little.