I blasted through the second sub in R&G using Charlie’s Angels in every node other than the three essential nodes, all six clears, without using a single health pack. (Used IM40 & Strange for the essentials.) The first four clears took an hour. The second two clears took 40 minutes. That’s about the fastest I can accomplish with my roster, though I probably could have shaved a couple of minutes by using a Thanos team on the first 2-3 easy nodes.
(Normally I like a little more team variety, but it was pretty fun seeing how far Chuck and his ladies could take me.)
I was using that team early on too, and it wasn’t uncommon to have a first round victory, even with just a 3-chain cascade. When Star-Lord boosts Grocket’s strike tiles, just the match damage alone is pretty brutal.