I swear I thought 4thor would be next on the 4* DDQ. Unfortunately, it is a recent 4*.
I have him 3/0/1 and am curious as to which pairings would be fair, fun, and relevant.
My guess, though biggest fear: 3* deadpool
vs
It will probably be Deadpool vs. Deadpool but at least that means you just need to deny the same colors that you look to match.
vs
with a
Patch.
Squirrel Girl!
Or She-Hulk, for a fourth-wall showdown!
I figured it would be 2* Wolverine. for story’s sake. But yeah, Deadpool makes the most sense now I think of it =)
if its deadpool (and that makes a ton of sense), no chance unless you have plenty of red covers and leveled decently. 6 red and some match damage and you’re done unless you can heal some, and that is expensive to boot.
Oh, imagine the pain of your Level 150 Deadpool trying to do attacks to slow down Wolvie and slowly wittle down his health
When the tiles drop, and he matches yellow.
Undoing the last two Out of Bullets you shot out.
That’ll be fun.
This would my guess. They said it would be the most interesting challenge yet. His tiles and regen qualify I’d think.
Matching away his tiles and leaving ones for yourself are very puzzle questy. I hope this happens, even if I don’t have xfdp myself 
…and 3pool gets super whales… 
Also doesn’t help that XDP’s black is completely useless without having someone else take damage.
Deadpool’s nemesis, Bagman.
Much like Hulkbuster fighting Hulk, I think Deadpool fighting anybody but himself would be a letdown for me.
That being said, I would probably let them get away with fighting Bag-Man given the in-game history. 
Clearly his enemy will be another 4Pool. Only he gets a Surgical Strike team-up.
Unleeeeeeeeeess they give you a Level 15 Bagman to team up with!
Useless on his own, but tanks one color hopefully so you can make him take an ability hit to activate X-Enforcer, hopefully!
I think patch would be hella easy. Let him get his green, then use XDP’s purple to cover all of his green tiles (or at least 6). Then, assuming you haven’t matched away all of the purple, he will give you a bunch of purple strike tiles while he gets little to none of his own. But, it at least offers some ‘puzzle’ aspect to it other than collect red AP, smack faces.
The interesting challenge comes next, which I fully expect to be PX vs Patch.
That’s kinda what I was thinking.
I figured if it wasn’t Deadpool he fights, it would likely be Wolverine. XForce wouldn’t make much story sense, Patch would be kinda easy with the right board…only Wolverine Classic would offer a challenge after that.
I mean you could time Countdown for What for when XForce gets Surgical Strike and end up wiping him out that way.
If they wanted another Xforce battle they could also run DP against Psylock. 6 black would wipe out my little Deadpool.