I have:
5* - all rostered, best have 11 covers, all are at base level 255
4* - 25 champed, 18 max covered (I could use over 5 mil Iso8 just for them), 3 at 8-11 covers and Coulson missing so far
3* - all champed, best are level 238, only Dr. Strange and Thanos are under level 200
2* - all champed. My strategy is to make a dupe when main is at level 139-141. I have then a use for covers when dupe has 5 in one color and is waiting for other colors. When main is level 144 and dupe max covered, I sell main and use gained iso for champing dupe.
1* - all max covered, max level
So, I don’t see any reason to change my roster or plans due to new DDQ. My plan is to finish champing 4* (should take around 4 months at current pace) and then start leveling 5*.