I would love to see a character made specifically for Marvel Puzzle Quest, then adapted to at least a limited run comic.
This way the character design can be centered around what is needed/works/fun for the game, and the look and powers of the character can be built around that.
The end goal would a character that is tailored to the game, but retains appeal for comic fans.
Community involvement in the development of the character, and possibly a different version for each rarity level, (1-5*) could peak player interest and show inclusion for the community.
Just an idea.