Here are strategies a great team. Are there others?
SPEED – Spidey, Rags, Mags. 2AP skills can deploy fast.
DAMAGE – Wolverine, Daken, BW Grey, Ragnarok, Thor. Build up AP, then unleash massive damage.
STUN – Spidey, Venom, Capt Amer, BW. Non-moving people won’t hurt you.
MEATSHIELD – Hulk, Rags, Thor, IM40. Ignore the puny attacks of the enemies.
AP DOMINANCE – The Hood, BW: Orig, Storm Modern. Have more AP, and steal what the enemy has.
RETRIBUTION – C. Storm, Daken, Bullseye, Hulk. Enemy moves may hurt them.
All teams are basically variations of “putting damage on the opponent as fast as possible and mitigating damage while doing it.”
How you put the damage on them can vary and how you can mitigate that damage (either through stun, defense tiles or healing) can vary too .. but the goals remain about the same.