I imagine this topic surfacing the day after Venom Bomb reached the Sub with the dreaded Venom+Carnage+Minion node is no coincidence. I used to hate that node (still do, somewhat) back when I used to do all my PvE with IM40+Dr. Strange+WhateverGreenUserIsBoosted.
Later I discovered the awesomeness that is 3DocOck+3Hawkeye+Prowler on that node.
Now, I’m not a 5* Player, but I imagine there should be an apropriate 5* team to do those nodes with ease. I think the point is exactly to build your roster until you have strong enough characters to do those tougher nodes.