Which 5-stars to level up

Marvel Puzzle Quest MPQ Tips and Guides Roster and Level Help
1

I think I’m ready for the giant leap. I have all but the most recent ten or so four-stars champed and the biggest ones are 320+.

I have the following five-stars at 13 covers:
Thanos, Black Panther, OML, Doctor Octopus, Strange, Ghost Rider, Iron Man, and Thor.
All are level 255 except Thanos is 330 and OML 323.

The following are at 12 covers:
Daredevil, Hawkeye,Phoenix, Silver Surfer

I have 3.5M of ISO.

Should I make the leap? And if so, which ones should I champ? All input appreciated!

2

Shuri champed but Okoye is really undercovered (something like seven covers, I think).

3

Kitty is at seven. I also do have Bishop champed, if that matter any.

4

How much pvp do you play?

If you play predominantly pve, champ Thanos and never look back.