I went with Doom vs Venom - deny green, then yellow, let him match black to his hearts content to keep you healed, and a song as he can’t fire green and yellow close together, should be golden
My venom was only 411 but I have no champed 5s… nearing 2/3 of 4 transition completed.
i took agent venom to him with rainbow, black red and yellow boosters
smacked venom good and proper
I can’t take any credit for this. I saw it in the event thread. I was getting thrashed by sandman (I eventually beat him with 5* Hawkeye and a lucky board) so I went looking for help and this seemed like a top notch idea. Worked a charm for me against venom. He barely scratched me. I’m happy it helped someone else out too. 
Indeed, I had wasted 10-12 health packs on my strongest 5* to no avail. This has put the ‘puzzle’ back in MPQ for me 
I used RiRi on every single one of these 1vs1. None were ever in jeopardy.
Don’t forget, Stun does not equal Airborn. Bosses can’t go Airborn, but side nodes can.
Load up her blue and red and go nuts. If you have a board favoring the foe more than you, just knock them Airborn a few times and match it back to your favor.
Pick your favorite Support to help you out. I typically stick with Taskmaster’s Sword, which would have worked even better if any of these foes had a Hero affiliation. I was hoping Venom might, but alas he didn’t.
This is great if your 1v1 isn’t level 598 with 195k health.
Captain IW has worked well. Sometimes I wipe due to bad boards when for example the AI gets crit matches dealing 29,000 in one match 
Otherwise though Cap IW purple allows me to block the worst power of each opponent and buy time to nuke them with his red. That being said, I still have lost a few matches just to bad luck. It is unfortunate though I can see for some players based on roster options. I actually found Green Goblin the hardest of them all so far. That black power is so cheap and so much damage…hard to stop it even with Cap IW.
Personally I have enjoyed the challenge, it is not often that I actually lose matches in the game.
The current 1 on 1 node featured 5Kingpin. While there were probably faster options to take him down, I let Invisible Woman do her invisibility thing while chipping away at his health and firing her green (KP was regularly stealing blue so didn’t get to fire that often). I think KP was just short of 100K hit points (vs 15K IW :mrgreen: )
Although the start of the match was a bit hairy because it took a while to collect 7 yellow, it was just satisfying to see him powerless to do anything after she turned invisible. At one point he had 3 green repeater tiles out
I’m only on 4* scaling, but these nodes are becoming challenging. The Kingpin one must have been at about 410, or about 20 levels above my boosted IW Spider-Man. I hit him with Proportional Punch, which I misjudged slightly so it didn’t quite take him down.
It was touch and go, since I was having trouble collecting another 10 red, and each of his matches was taking off about 1.5k health. I just scraped over the line with a slither of health left.
Overall, I’ve found IW Spidey to work pretty well at my scaling level. With no partners he covers the board in web tiles. That in turn nullifies power damage (provided it isn’t accompanied by a stun like it was with Sandman). Then it is just a matter of collecting enough red.
This has been a challenge for once , 1 v 1 against a level 510 Foe
I didn’t have any trouble against the other side nodes but I agree with the OP scaling is a bit ridiculous
I’ve thought for a while that if scaling goes up then so should points available
fortunately I now have an alliance who can compete and play most days so we can get the required points but I’ve always felt that there should be ways to make up the shortfall on alliance events
Use Miles Morales for thoose nodes. Get purple and invis, easy kill.
Well, going invisible is useless against Doc Ock i have noticed. Apart from the fact i could hardly do any damage because he healed every 2 turns, matching that tile led to insta death.
For Doc Ock I had to switch up from GED to JJ. Other than that, not much of a problem.
Personally I found it kinda fun trying to figure out how to win…
I missed fighting both Venom and Doc Ock. 
Just fought Vulture, I tried denying black but he got airborne but I was pretty lucky that he landed but didn’t go straight back up allowing me to punch his stupid beak in with Infini-Spidey, the events MVP.
Cool. Vulture. The best 1v1 4* in the game. 60 levels higher than my highest level 5*
Great design!
Did you try shaking your fist and shouting “Get off my lawn” at him?
So far my Hulkbuster has had no problems with any of them.
All you 4* players saying “so-and-so had no problems” aren’t understanding the difference between 4* play and 5* play. 4*'s get a 100+ level boost (like Miles, IWSpider, Hulkbuster, among others). Give me a 100+ level boost on my 5*'s and I’ll join in your celebration of easy victories.
Well in fairness 5* players have enjoyed a massive advantage in PvE ever since SCL were introduced to add to their massive advantage in PvP so maybe forgive the 4* players getting carried away with their unanticipated sweet spot on this one? You guys will be back to crushing it in SCL9 in no time whilst the 4s go back to chugging along. Obviously for older 5* players this is probably annoying as you suffered at the hands of scaling for so long so hopefully the smug 4s don’t annoy too much.