Too difficult for me but then my Sandman is very undernourished 
and I’m outta Iso
Not too bad with my 275. Just make sure he can’t get blue. Stun when possible.
Lvl 299 5/5/3 Sandman got it first try easily. He stunned me a few times, but I returned the favor, and my stuns hurt more.
no trouble for 280 Sandman - I was saving up 20 yellow to use it twice but had already beaten him before then. I guess it helps that BSSMs purple passive doesnt provide him any benefit since sandman doesnt produce strike tiles
First try for my level 157 5/5/3 Sandman. I brought along Taskmaster’s Sword expecting more of a fight, but ol’ black suit didn’t do much the whole match. I got stunned once. I focused on green, so Spidey never had the chance to build up the 8,900 green he needs for his ability. I’m saving the token while I ponder if I want to crack the hoard for iHulk, Yelena, and Apoc.
I had 3/5/5 Lvl 175 Sandman sitting around with absolutely no clue what he did. I gave it a spin and Spidey crushed him with his cheap blue. So I figured why not and champed him for the LT’s and CP to spend on Pocchy/Yelena/iHulk. It was still a pretty close fight anyway but I managed it second time.
Still no iso to spare but…YES. Finally, my measly lvl 117 Sandman did it. 2 goes it took, starved him of blue and boosted all colours!
Obviously he toughened up for his 2nd bout 
It kind of amuses me that BSSM’s passive does him no good here, since whenever he’s invisible, I’m stunned, and couldn’t do anything anyway. I got to finish him off with Sand Smash, which was kind of cool, too!