i think your opponents seem manageable. It’s probably their high hp that makes you think twice about hitting them. If you are bleeding iso-8 from skipping teams, then I think you might want to consider other strategy. In the next PVP event, would it be possible to list down 10 teams and their levels that you are seeing?
I’m not 100% about the availability of seed teams. Other players reported not seeing seed teams sometimes even though they entered as soon as possible. I guess some other players are just faster.
How does your roster look like? Did you enter your roster into MPQ Gamependium?
R4G is 4* Rocket & Groot. R4G, (any member from Guardian of the Galaxy) and Juggernaut is currently the meta/speed team for PvEs in 4* land.
The general advice is to build your 2*, followed by 3*, then 4* roster. 2* farming will help you to generate various resources so that you can progress a little faster.