Which character is your absolute least favorite to fight? Note this has nothing to do with the quality or power of the character, just how irritating they are.
Daken is the first one to come to mind, it’s like they purposely chose to create a character with three incredibly annoying abilities…
She-Hulk is way up there, as her Furious Charge always seems to furiously charge the AP I needed to cast Full Blast, Embiggened Bash, Optic Blasts, Keep your Enemies closer, etc., while leaving my unusable AP pools intact.
Kamala Khan for those horrifying cascade-heal-loops where the enemy casts 5+ abilities in one turn, and you’re looking at an enemy team with 90%+ health while your own team is nearly dead.
It’s probably still The Hood. Even though I’ve moved into the 4* tier and his low health pool should mark him as trivial as a speed bump for a hovercraft, he always seems to be just healthy enough that I’ve forced to either spend a few more turns letting him leech AP while I whittle him down with match damage or waste a perfectly good nuke on finishing him off.
I still hate Bullseye and his accursed protect tiles. No matter what I do it seems to magically set him up for purple matches every turn. Same with Daken and blue. It’s a toss up between those two.
Red Hulk
That guy is a pain in the butt to fight. He has a super huge amount of health and every time I think I’m about to get a 
power off he uses his Gamma Syphon to wreck my plans.
Bagman. Definitely bagman. Hate to see him out there, yep. Please don’t use him, whatever you do!
Tied For 1st - all the Dark Avengers. It’s time to move on from them, devs.
Carnage, his constant animations makes me want to have a seizure.
Carnage and by extension the symbiote goons. Their abilities constantly going off leaves me feeling like I’m not even getting to play the game.
Juggs… easily, especially when he is over-scaled. Cheap abilities and for some strange reason every time he does his green, he gets tons of red cascades and we know how that ends. The last event had arguably a Venom Bomb level annoyance for me with Hood draining for Venom and Juggs cheap abilities and Hood having tons of health so it was hard to OHKO him.
Also 6 AP for the amount of damage he does when he has been over-scaled, has always been wrong.
Brilliant 
Mutation. Carrier. Horror. In any combination and especially when paired with a tile mover who can use the AP they generate.
Rulk purple is maddening. Hood and Daken are awful, but at least you don’t have to worry about them when you’re not fighting them (barring a one-off Daken blue TU). Gamma Siphon seems to show up EVERYWHERE.
Axwolvie paired with red producing ninjas/konran and to a lesser extent, him with shield goons.
All Hulks and Captain Marvel. You have to stun them on nuke them in one turn.
Why stop at one? Here’s my top 10
Daken - two extremely annoying passive abilities. They made a lazy version of THIS?!
Hood - pair him with Juggernaut and an AP feeder for extra “fun”
Juggernaut - 
into cascade into more
into cascade into 
. Super tanky too.
Kishu or whatever that caltrops ninja is called - almost always a high priority target. Kill him with fire!
2* Bullseye - there just to slow things down. Mostly unable to do any serious damage by himself
3* Sam Wilson - like Daken, two passive abilities that make you want to scream in agony, especially in mirror matches
Lieutenant - his healing CDs popping up everywhere feel like an unfair game of whack-a-mole
Muscle - horribly broken, will eat your health packs for breakfast
1* Venom - truly annoying when able to paralyze your whole team and you just sit there and watch other dark avengers do unfunny things to you
Carnage - STAHP.
Fucking Kamala Khan. Fights take ages because she heals back to full off a massive AI cascade. Then you have to start all over. Time consuming and a huge waste of health packs. Glad her boosted week and immediately followed event are finally over!
Those two and I will add Hood for obvious reasons. Specially now that he can easily have 10k+ hitpoints in PvE
Rhulk syphon is also annoying but specially as a team up, which is super popular :S
No doubt. Confirmation bias whatever, there is no way this crap is random. I think I’ve seen it not hit my strongest color, like, once.
You say that but a team used him as a TU tile that completely screwed me. I was just about to get the purple I needed from SW when that fired off, raised the timer back up to 3 while they finished SW off. Never got enough purple again and ended up losing the match 8I