Well since I will no longer be able to keep updating this as I will no longer be able to whale new 4* releases anymore I thought I’d just close the thread out with the state of the 4* tier as of January 14, 2016. From here on out I’ll be guessing how good something is at max just like everyone else.
The top tier, the ones you should pray to get covers for and the ones you should spend time leveling up.
Iceman
Hulkbuster
Jean Grey
Classic Cyclops
Red Hulk
These five this is where all effort should be placed when transitioning into the 4* realm. Getting any two of these to level 220 or higher will allow for you to do much better in any event you want to enter.
The situational tier, the ones which go better with other characters but aren’t quite good enough on their own.
Ant-Man (Carnage)
Carnage (Ant-Man 4Venom)
Prof X (Flaptain/Ghost Rider and winfinite)
Thing (4Deadpool)
Kingpin (Any Countdown generator, 4* Venom, 535 Hulkbuster)
Elektra( Doc Ock/ Patch-try it on your next muscle goon PvE node)
4* Deadpool (Thing)
Nick Fury ( Really only good when buffed and you need a blue user)
Flaptain (His protect tiles plus blue ability to buff them will become more useful the more match damage becomes a thing you need to control)
X-Force Wolverine (4Thor)
4 Thor (X-Force Wolverine)
If for some reason you have well-covered versions of the partners it might be worth concentrating your efforts on leveling the other half. Fury and Flaptain are the last ones you should be concentrating on.
The ones that go very well with the 5* characters if you’re fortunate enough to have one.
X-23 (plays well with daddy Old Man Logan)
Ghost Rider
4* Venom
Miles Morales
The trash tier which you should sell for iso because they have zero use.
Star-Lord (The best of these three but still not worth investing in)
Invisible Woman
Reed Richards
And the absolute worst 4* ever The Totally Awesome (horrendous) Hulk
Devil Dino has his own tier as he should be on every roster at 111 just as a trophy which signifies one year of play.
I have been happy to be your source of information for the last two years on max new characters as they are released. The Guys at Demiurge no longer want that to be happening and so I leave you with this final ranking. Colognoisseur out!